| Astrocytes Aqp4 Gpc5 - Apoe | Astrocytes Aqp4 Gpc5 - Tprkb | Astrocytes Slc1a3 Slc7a11 - Cped1 | Astrocytes Slc1a3 Slc7a11 - Ranbp3l | Bergmann Gdf10 Gria1 - Gria1 | |
|---|---|---|---|---|---|
| Xkr4 | 0.2160268 | 0.2216736 | 0.2404465 | 0.4221899 | 0.7699403 |
| Gm1992 | 0.0210700 | 0.0077600 | 0.0735336 | 0.0498822 | 0.1123058 |
| Gm37381 | 0.0166807 | 0.0128804 | 0.0215986 | 0.0082632 | 0.0170091 |
| Rp1 | 0.0498806 | 0.0614188 | 0.0074269 | 0.0249311 | 0.0491225 |
| Sox17 | 0.0048606 | 0.0053718 | 0.0000000 | 0.0000000 | 0.0061107 |
| Astrocytes Slc1a3 Apoe - Slc1a2 | Astrocytes Slc1a3 Grin2c - Slc1a2 | Astrocytes Slc1a3 Ptgds - Ptgds | Endothelial Cldn5 Flt1 - Bsg | GABAergic Npy Adarb2 - Grip1 | |
|---|---|---|---|---|---|
| Xkr4 | 2.717575 | 0.8348435 | 1.8546009 | 1.580576 | 6.8728476 |
| Gm1992 | 0.000000 | 0.0191590 | 0.1427593 | 0.000000 | 0.2583325 |
| Gm37381 | 0.000000 | 0.0237413 | 0.0000000 | 0.000000 | 0.0463138 |
| Rp1 | 0.000000 | 0.0432075 | 0.0000000 | 0.000000 | 0.0453302 |
| Sox17 | 0.000000 | 0.0000000 | 0.0000000 | 1.013113 | 0.0000000 |
| Astrocytes Slc1a3 Hepacam - Apoe | Astrocytes Slc1a3 Hepacam - Cst3 | Astrocytes Slc1a3 Hepacam - Slc1a3 | Astrocytes Slc1a3 Mertk - Gpc5 | Astrocytes Slc1a3 Plpp3 - Apoe | |
|---|---|---|---|---|---|
| Xkr4 | 3.4593642 | 3.1257874 | 3.006409 | 1.2922381 | 0.8926728 |
| Gm1992 | 1.4871213 | 1.4236178 | 1.233734 | 0.0549860 | 0.1668951 |
| Gm37381 | 0.0325659 | 0.0157422 | 0.000000 | 0.0000000 | 0.0000000 |
| Rp1 | 0.0381125 | 0.0136421 | 0.000000 | 0.0131356 | 0.0000000 |
| Sox17 | 0.0000000 | 0.0151990 | 0.000000 | 0.0000000 | 0.0000000 |
| Astrocytes Slc1a3 Car2 - Cd81 | Astrocytes Slc1a3 Car2 - Glul | Astrocytes Slc1a3 Gpc5 - Gpc5 | Astrocytes Slc1a3 Gpc5 - Slc1a3 | Dopaminergic Rxfp1 Ntng2 - Ntng2 | |
|---|---|---|---|---|---|
| Xkr4 | 4.4754240 | 5.0894768 | 0.8558702 | 0.7277140 | 6.0490904 |
| Gm1992 | 2.3226102 | 2.1724244 | 0.0320016 | 0.0000000 | 0.5854197 |
| Gm37381 | 0.0385550 | 0.0517933 | 0.0082961 | 0.0000000 | 0.0000000 |
| Rp1 | 0.0775233 | 0.0000000 | 0.0081012 | 0.0000000 | 0.0000000 |
| Sox17 | 0.0000000 | 0.0550306 | 0.0081034 | 0.0855263 | 0.0000000 |
| Astrocytes Aqp4 Apoe - Apoe | Astrocytes Slc1a3 Brinp3 - Cdh18 | Astrocytes Slc1a3 Brinp3 - Gpc5 | Astrocytes Slc1a3 Brinp3 - Hs3st4 | Astrocytes Slc1a3 Erbb4 - Cntnap2 | |
|---|---|---|---|---|---|
| Xkr4 | 0.8525836 | 5.4301929 | 4.8089745 | 5.3186612 | 6.0951426 |
| Gm1992 | 0.3703344 | 3.0330123 | 2.2403751 | 2.1420419 | 3.5548043 |
| Gm37381 | 0.0071477 | 0.0000000 | 0.0000000 | 0.0442252 | 0.0192348 |
| Rp1 | 0.0101238 | 0.0667335 | 0.0538529 | 0.0000000 | 0.1012159 |
| Sox17 | 0.0165821 | 0.0329424 | 0.0000000 | 0.0463407 | 0.0000000 |
| Astrocytes Slc1a3 Plpp3 - Apoe | Astrocytes Slc1a3 Plpp3 - Cst3 | Dopaminergic Cck Hs3st4 - Ptprd | Dopaminergic Rxfp1 4933413l06rik - Pex5l | GABAergic Npy Erbb4 - Erbb4 | |
|---|---|---|---|---|---|
| Xkr4 | 1.0848248 | 1.1714033 | 2.7680306 | 3.9451423 | 5.2902240 |
| Gm1992 | 0.4413108 | 0.5016723 | 0.9104245 | 1.2229372 | 1.9764989 |
| Gm37381 | 0.0000000 | 0.0711501 | 0.0000000 | 0.0897211 | 0.0000000 |
| Rp1 | 0.1165463 | 0.0752031 | 0.0683943 | 0.0000000 | 0.1730269 |
| Sox17 | 0.2134944 | 0.2914689 | 0.0000000 | 0.0000000 | 0.0000000 |
| Astrocytes Slc1a3 Aqp4 - Clu | Astrocytes Slc1a3 Aqp4 - Slc1a2 | Cholinergic Calb1 Slc5a7 - Acly | Cholinergic Tacr1 Npy - Tacr1 | Endothelial Cldn5 Ly6c1 - Sparc | |
|---|---|---|---|---|---|
| Xkr4 | 0.0000000 | 0.0000000 | 0.0000000 | 0.000000 | 0.0421118 |
| Sox17 | 0.0000000 | 0.0000000 | 0.0000000 | 1.761456 | 1.9647710 |
| Mrpl15 | 0.0000000 | 0.9133879 | 0.7388574 | 3.035198 | 0.5635974 |
| Lypla1 | 0.9655279 | 0.7947375 | 0.0000000 | 4.204058 | 1.1343567 |
| Tcea1 | 1.2686132 | 1.9388918 | 0.7489950 | 4.482223 | 1.5668944 |
| Dopaminergic Adcyap1 Uncx - Ndn | Dopaminergic Adcyap1 Uncx - Pitx2 | Dopaminergic Lmx1a Uncx - Dmrta2 | Endothelial Cldn5 Igfbp7 - Sparc | GABAergic Npy Asic4 - Gata3 | |
|---|---|---|---|---|---|
| Xkr4 | 0.0000000 | 0.0000000 | 0.000000 | 0.000000 | 0.0973496 |
| Sox17 | 0.0000000 | 0.0000000 | 0.000000 | 1.989048 | 0.0000000 |
| Mrpl15 | 1.3528010 | 1.5724406 | 2.255019 | 2.333679 | 1.7855451 |
| Lypla1 | 0.9502086 | 0.2416054 | 0.435312 | 2.630886 | 1.0604708 |
| Gm37988 | 0.0000000 | 0.0000000 | 0.000000 | 0.000000 | 0.0000000 |
| Astrocytes Slc1a3 Gja1 - Atp1b2 | Astrocytes Slc1a3 Gja1 - Slc1a3 | Astrocytes Slc1a3 Gja1 - Slc6a11 | Endothelial Cldn5 Flt1 - Cldn5 | Endothelial Cldn5 Flt1 - Itm2a | |
|---|---|---|---|---|---|
| Xkr4 | 0.1478369 | 0.0000000 | 0.0000000 | 0.0389687 | 0.0426850 |
| Gm1992 | 0.0000000 | 0.0000000 | 0.0000000 | 0.0000000 | 0.0000000 |
| Rp1 | 0.0000000 | 0.0000000 | 0.0000000 | 0.0786196 | 0.0923171 |
| Sox17 | 0.0000000 | 0.0217464 | 0.0000000 | 3.4246754 | 2.6691677 |
| Mrpl15 | 0.4358399 | 0.5520658 | 0.4324584 | 0.6034894 | 0.8981087 |
| Astrocytes AGT CCL2 - AGT | Astrocytes AQP4 HEPN1 - AQP4 | GABAergic TAC3 DLX6-AS1 - SOX4 | Glutamatergic SSTR2 RP11-93H24.3 - TUBA4A | NPCs FOXG1 C4ORF32 - C11ORF96 | |
|---|---|---|---|---|---|
| RP11-34P13.3 | 0.0000000 | 0.000000 | 0.0000000 | 0.000000 | 0.0000000 |
| RP11-34P13.7 | 0.0000000 | 0.000000 | 0.0057023 | 0.000000 | 0.0000000 |
| FO538757.2 | 2.5167939 | 1.393544 | 1.2805036 | 2.050920 | 2.1861439 |
| AP006222.2 | 2.7259739 | 1.445707 | 0.5640264 | 1.171028 | 0.8439073 |
| RP4-669L17.10 | 0.0286725 | 0.000000 | 0.0053284 | 0.000000 | 0.0000000 |
| Cell_name | Function_gene | biological_process | cellular_component | molecular_function |
|---|---|---|---|---|
| Astrocytes Slc1a3 Hepacam - Apoe | APOE | cholesterol metabolic process | extracellular space | amyloid-beta binding |
| Astrocytes Slc1a3 Hepacam - Cst3 | CST3 | defense response | extracellular space | amyloid-beta binding |
| Astrocytes Slc1a3 Hepacam - Slc1a3 | SLC1A3 | L-amino acid transport | plasma membrane | organic acid:sodium symporter activity |
| Astrocytes Slc1a3 Mertk - Gpc5 | GPC5 | protein localization to membrane | cell surface | protein binding |
| Astrocytes Slc1a3 Plpp3 - Apoe | APOE | cholesterol metabolic process | extracellular space | amyloid-beta binding |
| cell_names | p_Apoe | subclass_DE_Apoe | global_DE_Apoe | region |
|---|---|---|---|---|
| GABAergic Sst Nxph1 - Grip1 -> GABAergic Sst Nxph1 - Kcnmb2 | 0.8399968 | -0.0543533 | -0.0055550 | auditory_cortex |
| GABAergic Sst Nxph1 - Kcnmb2 -> GABAergic Sst Nxph1 - Grip1 | 0.8399968 | 0.0543533 | 0.0487983 | auditory_cortex |
| GABAergic Vip Adarb2 - Adarb2 -> GABAergic Npy Adarb2 - Erbb4 | 0.0518980 | 0.3750681 | 0.1325001 | auditory_cortex |
| GABAergic Npy Adarb2 - Erbb4 -> GABAergic Vip Adarb2 - Adarb2 | 0.0518980 | -0.3750681 | -0.2425680 | auditory_cortex |
| Glutamatergic Cck Tox - Pex5l -> Glutamatergic Cck Tox - Malat1 | 0.0000000 | -1.1674819 | -0.8746888 | auditory_cortex |
The analysis was performed through the non-profit and open-source pipeline JSEQ®. Pipeline belongs to the part of the JBioSystem project in which we create complex software for bioinformatics analysis. Remember in silico analysis can not be taken for granted and must be validated in vitro or in vivo. For more information go to GitHub or contact us. The JSEQ® was created in the Department of Molecular Neurobiology, Institute of Bioorganic Chemistry, Polish Academy of Sciences
Brain structures:
Human brain organoids: